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Introduction to ILUVIEN

ILUVIEN provides continous microdosing of fluocinolone acetonide (FAc ) release. Allowing you to treat DMO for up to 3 years (ref SPC and Campo 2012).


ILUVIEN is 3.5 mm in length, 0.37 mm in diameter with a volume that is 10,000 times less than the volume of the vitreous.

The external capsule is made from polyimide, an inert material used in the haptics of intra-ocular lenses.

ILUVIEN has a non-permeable plug at one end. At the other end is a permeable membrane made of poly-vinyl alcohol, or PVA that allows the molecular passage of fluocinolone acetonide.

The internal part of the implant consists of a PVA matrix + fluocinolone acetonide molecules. (ref technology video?).

The continuous microdosing technology in ILUVIEN can provide a stable release of corticosteroid for up to 3 years (ref SPC and Campo 2012)

Aqueous levels of Fluocinolone acetonide in human eyes

Data presented as mean ± standard error

3. ILUVIEN, Summary of Product Characteristics. October 2015.
6. Campochiaro PA, et al. Ophthalmology 2012; 119: 2125-2132.

FAc = Flucocinolone acetonide


ILUVIEN’s applicator has a 25 gauge needle, which produces a self-sealing wound, with no need for a tunnelling procedure. The injection is simple and is performed at 4 mm inferotemporal from the limbus. As there is no spring in the device, the implant is “smoothly” delivered into the posterior part of the eye, where it settles in the vitreous and starts releasing the fluocinolone acetonide (FAc). (Ref: technology video?)

ILUVIEN implant is injected by a direct injection technique. Injection should be done perpendicular to the sclera.